The area of this room is virtually the same as that of the French room, but the dimensions are different and it has a gallery measuring 35 m². The decor and interior design work, together with the furniture, were a gift from the Government of Czechoslovakia, presented on 15 September 1937.

The mural, in brass wire against a light blue background, depicts 8 of the 12 signs of the Zodiac: Pisces, Capricorn, Scorpio, Libra, Virgo, Leo, Gemini and Sagittarius. The other four signs, Aries, Taurus, Cancer and Aquarius, are not shown. The room is furnished with numerous pieces in varnished walnut, and the whole suite of sofas, armchairs, chairs and stools is upholstered in light grey leather. The parquet floor is laid in a checked pattern. This room and room X are the only two in the Palais with wood flooring. The decor makes use of glass rods, which were in widespread use from the early 1930s onwards: opaque white rods for the large ceiling light and the writing desk.

In 1994-1995, the Czech and Slovak Governments renovated the room completely. Although the former Czechoslovakia had been divided into two independent republics in 1993, the two new States undertook to share the cost of renovation and the room is now named for two countries: the Czech and Slovak Room. The old furniture was restored and new pieces made in the same style. A commemorative plaque was placed at the entrance to the room, on the left.